Linked Life Data

3371796

Source:http://linkedlifedata.com/resource/pubmed/id/3371796

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-6-30
pubmed:abstractText
To elucidate the anti-ulcer mechanism of mezolidon (KM-1146, 2-(3,4-dimethoxyphenyl)-5-methylthiazolidine-4-one), we investigated gastric mucosal blood flow (laser-Doppler method), transmucosal potential difference, gastroduodenal mucosal surface pH and blood viscosity in rats under a water-immersion stress condition. In the control group, gastric mucosal ulcers occurred three hours after the onset of water-immersion. At that time, gastric mucosal blood flow decreased to 40% and the potential difference decreased to 48%. In the mezolidon-pretreated group, gastric mucosal ulcers were significantly reduced, and the potential difference was significantly higher than in the control group. Gastric mucosal blood flow increased significantly to 120% twenty minutes after the onset of water-immersion and then decreased, but was significantly higher than in the control group. Gastroduodenal mucosal surface pH was not affected by the pretreatment with mezolidon under this condition. Pretreatment with mezolidon did not affect blood viscosity. In conclusion, the anti-ulcer effect of mezolidon may involve the increase and/or maintenance of gastric mucosal blood flow, but more investigations are necessary to understand the mechanism involved.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0015-5691
pubmed:author
pubmed:issnType
Print
pubmed:volume
91
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
121-7
pubmed:dateRevised
2011-7-27
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
[Anti-ulcer mechanism of mezolidon on water-immersion stress induced gastric ulcers in rats].
pubmed:affiliation
Department of Geriatric Medicine, Faculty of Medicine, Kyoto University, Japan.
pubmed:publicationType
Journal Article, English Abstract