Linked Life Data

3368993

Source:http://linkedlifedata.com/resource/pubmed/id/3368993

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-6-13
pubmed:abstractText
Decompression sickness is caused by the production of tissue and blood stream inert gas bubbles. Perfluorocarbon emulsions (PFC) have enhanced O2 and N2 solubilities as well as a small particle size as properties. The effects of treatment with a PFC (FC-43) and 100% oxygen on decompression sickness were investigated in 24 Sprague-Dawley rats compressed to 6.8 ATA and rapidly decompressed. Survival in animals receiving PFC and 100% oxygen was significantly longer (P = 0.01) than in those receiving a 6% hetastarch (H) treatment. The PFC survivors at 24 h did not demonstrate any neurologic deficits, whereas the 1 H animal surviving at 24 h was ataxic and not eating. Those animals who died most often did so within minutes after decompression, suggesting a hemodynamic demise. We conclude that PFC treatment when coupled with 100% oxygen breathing provides both hemodynamic and neurologic protection from decompression sickness.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0093-5387
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Treatment of decompression sickness with a perfluorocarbon emulsion (FC-43).
pubmed:affiliation
Department of Anesthesia, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL 60612.
pubmed:publicationType
Journal Article