Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
1988-6-22
|
pubmed:abstractText |
Isolated uterus and colon segments were taken from sennoside-pretreated female rats. They indicate a possible decrease in spontaneous contractility of both organ segments. Addition of rhein-Na, as one of the probable active metabolites of sennosides, into the bath medium of isolated colon and ileum segments of untreated rats showed a reduction in contractility at concentrations of more than 10(-5) and 10(-4) mol/l, respectively. Though rhein-Na in concentrations of more than 10(-4) mol/l impaired acetylcholine-mediated contractures of isolated colon, the antagonism was obviously partial and noncompetitive. Isolated uteri from previously estrogen-treated rats did not show a change in the contractile behaviour up to concentrations of 10(-4) mol/l rhein-Na, whereas higher concentrations induced an increase in contractions. The importance of this finding is not clear.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
0031-7012
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
36 Suppl 1
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
57-65
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3368526-Acetylcholine,
pubmed-meshheading:3368526-Animals,
pubmed-meshheading:3368526-Anthraquinones,
pubmed-meshheading:3368526-Colon,
pubmed-meshheading:3368526-Female,
pubmed-meshheading:3368526-Gastrointestinal Motility,
pubmed-meshheading:3368526-Ileum,
pubmed-meshheading:3368526-Rats,
pubmed-meshheading:3368526-Rats, Inbred Strains,
pubmed-meshheading:3368526-Uterine Contraction
|
pubmed:year |
1988
|
pubmed:articleTitle |
In vitro effects of anthraquinones on rat intestine and uterus.
|
pubmed:affiliation |
Department of Pharmacology, Dr. Madaus GmbH & Co., Cologne, FRG.
|
pubmed:publicationType |
Journal Article,
In Vitro
|