Linked Life Data

3368195

Source:http://linkedlifedata.com/resource/pubmed/id/3368195

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-6-23
pubmed:abstractText
We have performed a series of experiments to determine directly whether bile acids influence carcinogenesis, using a C3H/10T1/2 cell transformation system in vitro. Treatment of the cells with the carcinogen, 3-methylcholanthrene (MCA), followed by the addition of lithocholic acid (LCA), produced a marked increase in the number of transformed foci as compared to the number induced by MCA alone. Simultaneous treatment with MCA and bile acid did not increase the number of transformed foci except in the case of MCA in combination with LCA. When cultured cells were exposed to MCA soon after removal of cholic acid or LCA, a statistically significant increase in the number of transformed foci was noted. When cultured cells were replated after continuous exposure to test compounds and then treated with MCA, no enhancement of the rate of formation of transformed colonies was observed. From these results, it appears that bile acids act as not only promoting but also as co-carcinogenic agents under certain circumstances.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0030-2414
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
192-6
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Cocarcinogenic activity of bile acids in the chemical transformation of C3H/10T1/2 fibroblasts in vitro.
pubmed:affiliation
First Department of Surgery, Tottori University School of Medicine, Yonago, Japan.
pubmed:publicationType
Journal Article