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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1988-6-21
|
| pubmed:abstractText |
In rats bled to invariably fatal haemorrhagic shock (mean arterial pressure = 18-24 mmHg), the prompt and sustained improvement of cardiovascular function, obtained with the i.v. injection of cholecystokinin octapeptide (CCK-8, 20 g/kg) is associated with a massive increase in the volume of residual circulating blood (0.69 +/- 0.12 ml/100 g b.w. in saline-treated rats; 1.61 +/- 0.09 ml/100 g b.w. in CCK-8-treated rats). The number of red cells/mm3 and the % Hb content is the same in CCK-8-treated and in control rats. So, in a condition of severe haemorrhage, otherwise incompatible with survival, the i.v. injection of CCK-8 not only induces an impressive increase in arterial pressure and in circulating blood volume, but also greatly improves tissue oxygenation.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0143-4179
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
69-72
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3368038-Animals,
pubmed-meshheading:3368038-Blood Pressure,
pubmed-meshheading:3368038-Blood Volume,
pubmed-meshheading:3368038-Erythrocyte Count,
pubmed-meshheading:3368038-Female,
pubmed-meshheading:3368038-Injections, Intravenous,
pubmed-meshheading:3368038-Rats,
pubmed-meshheading:3368038-Rats, Inbred Strains,
pubmed-meshheading:3368038-Shock, Hemorrhagic,
pubmed-meshheading:3368038-Sincalide
|
| pubmed:articleTitle |
Haematological changes induced by the intravenous injection of CCK-8 in rats subjected to haemorrhagic shock.
|
| pubmed:affiliation |
Institute of Pharmacology, University of Modena, Italy.
|
| pubmed:publicationType |
Journal Article
|