Linked Life Data

3367708

Source:http://linkedlifedata.com/resource/pubmed/id/3367708

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-6-16
pubmed:abstractText
Ito cells (FSC) have been thought to be collagen-producing cells with regard to hepatic fibrosis. We have found that desmin, a structural protein of muscular intermediate filaments, is found in the cytoplasm of FSC, even in negative vitamin A-autofluorescence FSC, by using immunocytochemical techniques. In the present study, numbers of FSC produced by the administration of heterogeneic serum or carbon tetrachloride were detected in fibrous and non-fibrous areas of hepatic lobules by using a morphometrical analyser. After 8 weeks of intraperitoneal injections of heterogeneic serum into rats, FSC in fibrous septa increased in number and the increase continued to 12 weeks-although the numbers of FSC in non-fibrous areas and in controls given homologous serum did not change during the experiment. In the case of rats administered CCl4 once, FSC in fibrous areas increased in numbers after 48 h through 72 h, although the number of FSC in non-fibrous areas and in controls did not change. The results, with an apparent increase in numbers of FSC in fibrous areas and no change in non-fibrous areas, showed the possibility of hyperplasia due to cell division of FSC in the new fibroplastic areas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0106-9543
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
48-52
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Distribution of Ito cells in experimental hepatic fibrosis.
pubmed:affiliation
Department of Medicine, Juntendo University School of Medicine, Tokyo, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't