Linked Life Data

3366364

Source:http://linkedlifedata.com/resource/pubmed/id/3366364

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-6-20
pubmed:abstractText
Equilibrium behavior of two-locus mutation-selection balance models is analyzed using perturbation techniques. The classical result of Haldane for one locus is shown to carry over to two loci, if fitnesses are replaced by marginal fitnesses. If the fitness of the double heterozygote is smaller than would be produced by a multiplicative model, as in additive or quantitative fitness models, the disequilibrium is negative--an excess of gametes with one rare allele. In this case the disequilibrium can be as large as one-half its maximum value possible, if the recombination rate is small, not greater than the strength of selection. If the fitness of the double heterozygote is larger than would be produced by a multiplicative model, the disequilibrium is positive, and is very small relative to its maximum value possible, even if the recombination rate is zero.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
118
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
543-7
pubmed:dateRevised
2010-9-9
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Disequilibrium in two-locus mutation-selection balance models.
pubmed:affiliation
Department of Mathematics, University of California, Davis 95616.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.