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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1988-5-31
|
| pubmed:abstractText |
Stereologic methods were used to study lung development in sheep from 2 to 171 days of age. Most growth occurs within the first 2 months when there is a threefold increase in lung volume, but allometric relationships show that this increase does not keep pace with body weight. Alveolar and capillary surface areas increase as lung volume to a power only slightly larger than 1, suggesting a modest increase in complexity; this is confirmed by only a two- to threefold increase in total alveolar number. Allometric power functions are essentially unchanged even during the first 30 days so that throughout development, the surface for gas exchange is added at a fairly constant rate. A slight increase in septal volume during the first 30 days is probably due to relative increase in capillary luminal volume through a progressive distension of capillaries. The results suggest that the active newborn lamb requires an alveolar lung, but in the postnatal period functional needs increase only moderately. In contrast, other mammals, such as the rat, are helpless as newborns and have a primitive saccular lung that must undergo considerable morphogenesis to meet the demands of the active adult.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0003-276X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
220
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
281-6
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading | |
| pubmed:year |
1988
|
| pubmed:articleTitle |
Postnatal growth of the sheep lung: a morphometric study.
|
| pubmed:affiliation |
Department of Pathology, Children's Hospital, Boston, MA 02115.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|