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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1988-6-3
|
| pubmed:abstractText |
Laminin P1, a pepsin-resistant fragment of the glycoprotein laminin, was determined in body fluids using a double-antibody radioimmunoassay. The median serum concentrations found were: men 1.32, premenopausal women 1.22, postmenopausal women 1.38 and pregnant women (35th gestational week) 2.18 U/ml. The median concentration in amniotic fluid was 1.90, in urine 0.28 and in follicle cyst fluid 1.74 U/ml. During gestation, rising serum levels of up to 5 U/ml were observed which decreased within a few days after delivery. The cut-off value of laminin P1 for 95% specificity of the normal female control group was found to be 1.8 U/ml. The frequencies of elevated serum concentrations were 11, 18, 23 and 33% in patients with primary malignant lesions of the breast, endometrium, cervix and ovary, respectively, and rose up to 50-51% in patients with recurrent or metastatic gynaecological cancer. Laminin P1 was found in high concentrations in the cytosol fractions of breast cancer biopsies. Long-term sequential determinations of serum levels in 10 individual patients with progressive cancer reflected the course of the disease in 8 cases. Although laminin P1 can be considered as a tumour-associated protein, low sensitivity to primary cancer and insufficient specificity limit its application as a tumour marker and its usefulness in monitoring of patients with gynaecological cancer.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1010-4283
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
37-46
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3363285-Body Fluids,
pubmed-meshheading:3363285-Female,
pubmed-meshheading:3363285-Genital Neoplasms, Female,
pubmed-meshheading:3363285-Humans,
pubmed-meshheading:3363285-Laminin,
pubmed-meshheading:3363285-Male,
pubmed-meshheading:3363285-Peptide Fragments,
pubmed-meshheading:3363285-Pregnancy,
pubmed-meshheading:3363285-Radioimmunoassay
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Radioimmunoassay of laminin P1 in body fluids of pregnant women, patients with gynaecological cancer and controls.
|
| pubmed:affiliation |
Department of Obstetrics and Gynaecology, University of Cologne, FRG.
|
| pubmed:publicationType |
Journal Article
|