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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1988-6-7
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pubmed:databankReference | |
pubmed:abstractText |
To identify candidates for cis-acting sequences that regulate the stage and cell-specific expression of the two coordinately regulated protamine genes in the mouse, genomic clones were isolated and the nucleotide sequences of the 5' flanking regions and coding regions were compared. Unlike most histone genes and the multigene family of trout protamine genes which are intronless, each mouse protamine gene has a single, short intervening sequence. Although the coding regions do not share significant nucleotide homology, the 5' flanking regions contain several short homologous sequences that may be involved in gene regulation. An additional shared sequence is present in the 3' untranslated region surrounding the poly(A) addition signal in both genes.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0006-3002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
950
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
45-53
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3358932-Amino Acid Sequence,
pubmed-meshheading:3358932-Animals,
pubmed-meshheading:3358932-Base Sequence,
pubmed-meshheading:3358932-Gene Expression Regulation,
pubmed-meshheading:3358932-Genes,
pubmed-meshheading:3358932-Humans,
pubmed-meshheading:3358932-Male,
pubmed-meshheading:3358932-Mice,
pubmed-meshheading:3358932-Mice, Inbred C57BL,
pubmed-meshheading:3358932-Molecular Sequence Data,
pubmed-meshheading:3358932-Protamines,
pubmed-meshheading:3358932-Sequence Homology, Nucleic Acid,
pubmed-meshheading:3358932-Testis,
pubmed-meshheading:3358932-Trout
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pubmed:year |
1988
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pubmed:articleTitle |
Sequence homologies in the mouse protamine 1 and 2 genes.
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pubmed:affiliation |
Department of Biology, Tufts University, Medford, MA 02155.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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