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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1988-5-16
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pubmed:abstractText |
The relationship between the histocompatibility leukocyte antigen (HLA) phenotypes and the clinical course of myasthenia gravis (MG) was studied in 53 Japanese patients with MG. The frequency of HLA-DRw9 antigen was high in the MG patients who did not need immunosuppressive therapy but only anticholinesterase agents (RR = 4.52; CP less than 0.02), who achieved remission of the disease (RR = 2.98; CP less than 0.05) or who showed a decrease in AChR antibody (Ab) titer (RR = 6.32; CP less than 0.0002), whereas the frequency of HLA-DRw8 antigen was increased in MG patients who underwent immunosuppressive therapy (RR = 4.03; CP less than 0.01), who did not have remission (RR = 4.75; CP less than 0.1) or who showed an increase in AChR Ab titer (RR = 6.48; CP less than 0.01). These data suggest that immunogenetic heterogeneity in MG might be reflected in its clinical course.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
171-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:3356802-Adolescent,
pubmed-meshheading:3356802-Adult,
pubmed-meshheading:3356802-Aged,
pubmed-meshheading:3356802-Autoantibodies,
pubmed-meshheading:3356802-Child,
pubmed-meshheading:3356802-Child, Preschool,
pubmed-meshheading:3356802-Cholinesterase Inhibitors,
pubmed-meshheading:3356802-Female,
pubmed-meshheading:3356802-HLA Antigens,
pubmed-meshheading:3356802-HLA-DR Antigens,
pubmed-meshheading:3356802-HLA-DR Serological Subtypes,
pubmed-meshheading:3356802-Humans,
pubmed-meshheading:3356802-Immunosuppressive Agents,
pubmed-meshheading:3356802-Infant,
pubmed-meshheading:3356802-Male,
pubmed-meshheading:3356802-Middle Aged,
pubmed-meshheading:3356802-Myasthenia Gravis,
pubmed-meshheading:3356802-Phenotype,
pubmed-meshheading:3356802-Receptors, Cholinergic
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pubmed:year |
1988
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pubmed:articleTitle |
Involvement of HLA in clinical courses of myasthenia gravis.
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pubmed:affiliation |
Department of Pediatrics, Ehime University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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