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pubmed-article:3355995pubmed:abstractTextWe have cytogenetically investigated short-term cultures initiated from 34 uterine leiomyomas, all of which were histologically completely benign. Clonal chromosome abnormalities were detected in five cases, a normal female complement in 22, whereas, in the remaining seven tumors no karyotype could be established. Apparently identical reciprocal translocations, t(12;14)(q14-15;q23-24), were found as the sole abnormality in four tumors. The fifth abnormal case contained a t(2;14)(p11;p11). We conclude that chromosome aberrations may be found in myomas of the uterus, and that t(12;14)(q14-15;q23-24) characterizes a subset of these tumors.lld:pubmed
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pubmed-article:3355995pubmed:articleTitleA specific translocation, t(12;14)(q14-15;q23-24), characterizes a subgroup of uterine leiomyomas.lld:pubmed
pubmed-article:3355995pubmed:affiliationDepartment of Clinical Genetics, University Hospital, Lund, Sweden.lld:pubmed
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