|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1988-5-11
|
|
pubmed:abstractText |
Changes in the phosphorylation of platelet tubulin were analyzed as a function of platelet activation. Non-activated platelets incubated with [32P]-phosphate showed multiple peaks of radioactivity when solubilized platelet proteins were analyzed by SDS-polyacrylamide gradient gel electrophoresis. Both tubulin monomers were found to be phosphorylated. Agonistic stimulation (thrombin or 1,2-diacylglycerol) resulted in a lowering of the phosphate incorporation into alpha- and beta-tubulin. Such changes we believe are important in the modulation of the reversible polymerization-depolymerization of platelet tubulin that occurs in the course of the agonistic stimulation of platelets.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0006-291X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
30
|
|
pubmed:volume |
151
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1250-5
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:3355554-Autoradiography,
pubmed-meshheading:3355554-Blood Platelets,
pubmed-meshheading:3355554-Chromatography, Affinity,
pubmed-meshheading:3355554-Diglycerides,
pubmed-meshheading:3355554-Electrophoresis, Polyacrylamide Gel,
pubmed-meshheading:3355554-Humans,
pubmed-meshheading:3355554-Lactoperoxidase,
pubmed-meshheading:3355554-Phosphorylation,
pubmed-meshheading:3355554-Polymers,
pubmed-meshheading:3355554-Thrombin,
pubmed-meshheading:3355554-Tubulin
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
Agonist-induced changes of platelet tubulin phosphorylation.
|
|
pubmed:affiliation |
Division of Hematology/Oncology, Memorial Hospital of RI, Pawtucket.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
