Linked Life Data

3354661

Source:http://linkedlifedata.com/resource/pubmed/id/3354661

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4 Pt 1
pubmed:dateCreated
1988-5-11
pubmed:abstractText
The effects of vasoactive intestinal peptide (VIP) and related structural homologues on tissue vascular conductances were investigated in anesthetized male rats. VIP, peptide histidine isoleucine (PHI), secretin, growth hormone-releasing factor (GHRF), gastric inhibitory peptide (GIP), or saline was infused intravenously over 4 min. Tissue blood flows were measured during this time by use of 141Ce-labeled microspheres. Regional blood flows were normalized for any change in mean arterial blood pressure during infusions, and results were expressed in terms of tissue vascular conductance (C). Circulating thyrotropin (TSH), triiodothyronine (T3), and thyroxine (T4) levels were determined before and at 20 min and 2 h after treatment. Marked increases in thyroid, pancreatic, and salivary gland vascular Cs occurred during peptide infusions with the order of potency (VIP greater than PHI greater than secretin greater than GHRF greater than GIP) correlating with the degree of structural homology to VIP. PHI and secretin produced maximal increases in vascular Cs, which were the same as those obtained with VIP. Circulating TSH, T3, and T4 levels were not different from values in saline-infused rats after peptide treatments that caused striking increases in thyroid vascular C. In the adrenal, kidney, and testis, VIP and its homologues had little to no effect on vascular Cs. We subsequently measured regional vascular Cs during VIP infusions in the presence or absence of secretin.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
254
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
E435-42
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
VIP and its homologues increase vascular conductance in certain endocrine and exocrine glands.
pubmed:affiliation
Department of Physiology, West Virginia University Medical Center, Morgantown 26506.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.