Linked Life Data

3353426

Source:http://linkedlifedata.com/resource/pubmed/id/3353426

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-5-3
pubmed:abstractText
An experiment was performed to determine if the discriminative stimulus effects of morphine are modified by mild food deprivation, a condition that increases drug-reinforced behavior. Rats were trained to discriminate between SC injections of saline and morphine (3.0 mg/kg) in a discrete-trial shock-avoidance procedure. Stimulus generalization curves for morphine were then determined on three occasions by a cumulative-dosing procedure: before, during and after the body weight of the rats had been reduced to 86-87% of normal by restricted feeding. Food deprivation had little or no effect on the morphine generalization curve. Despite a close relationship between the reinforcing and discriminative stimulus properties of opioid drugs, stimulus control of behavior by morphine was not modified by a condition that enhances opioid-reinforced behavior.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
201-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Restricted feeding does not modify discriminative stimulus effects of morphine in the rat.
pubmed:affiliation
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.