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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1988-5-3
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pubmed:abstractText |
The electrophysiological effects of neurotensin (NT), its analog xenopsin, and the fragment NT-(1-8) on the activity of dopaminergic neurons in rat substantia nigra slices were compared. Xenopsin and NT produced a concentration-dependent increase in the firing rate. The mean firing rate was increased by 58.5% with xenopsin (0.1 microM) and 49.1% with NT (0.1 microM). NT-(1-8) was inactive at this concentration. Dopamine (100 microM) inhibited firing in these neurons by 54.7%. These data provide evidence that xenopsin mimics the physiological effects of NT.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-2999
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
145
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
341-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3350051-Action Potentials,
pubmed-meshheading:3350051-Animals,
pubmed-meshheading:3350051-Male,
pubmed-meshheading:3350051-Neurons,
pubmed-meshheading:3350051-Neurotensin,
pubmed-meshheading:3350051-Oligopeptides,
pubmed-meshheading:3350051-Peptide Fragments,
pubmed-meshheading:3350051-Peptides,
pubmed-meshheading:3350051-Pyrrolidonecarboxylic Acid,
pubmed-meshheading:3350051-Rats,
pubmed-meshheading:3350051-Rats, Inbred Strains,
pubmed-meshheading:3350051-Receptors, Dopamine,
pubmed-meshheading:3350051-Substantia Nigra,
pubmed-meshheading:3350051-Xenopus Proteins
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pubmed:year |
1988
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pubmed:articleTitle |
The neurotensin analog xenopsin excites nigral dopamine neurons.
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pubmed:affiliation |
Biology Research Department, Ciba-Geigy Ltd., Basel, Switzerland.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Case Reports
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