Linked Life Data

3349720

Source:http://linkedlifedata.com/resource/pubmed/id/3349720

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-4-28
pubmed:abstractText
To assess both ventricular function and myocardial perfusion, five normal volunteers, 19 patients with coronary artery disease, and two patients with cardiomyopathy and normal coronary arteries were injected with 20 mCi of Tc-99m isonitrile (either methoxyisobutyl isonitrile or carbomethoxyisopropyl isonitrile) at peak bicycle exercise and again at rest. A standard Tl-201 stress test was performed in all patients at the same level of exercise within one month of the isonitrile study. In all normal subjects, myocardial perfusion was normal at stress levels and the left ventricular ejection fraction increased 5% or more with exercise. In the 19 patients with coronary artery disease, the ejection fraction response to exercise was abnormal in 14 patients. Perfusion images with the Tc-99m isonitriles correlated well with Tl-201 images during exercise and at rest, with 89% concordance in areas of ischemia or infarction and 93% in normal segments. A simultaneous study of myocardial perfusion and ventricular function can be performed using a single Tc-99m labeled myocardial agent. Tc-99m isonitriles, particularly Tc-99m MIBI, result in sufficiently high photon flux that ventricular performance can be studied at peak exercise and again during rest using the first pass method.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0363-9762
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
77-81
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Simultaneous measurement of ventricular function and myocardial perfusion using the technetium-99m isonitriles.
pubmed:affiliation
Sanatorio Guemes, Buenos Aires, Argentina.
pubmed:publicationType
Journal Article