Linked Life Data

3349393

Source:http://linkedlifedata.com/resource/pubmed/id/3349393

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-5-5
pubmed:abstractText
The mechanisms and completeness of equine articular cartilage repair were studied in ten horses over a nine month period. Large (15 mm square) and small (5 mm square) full-thickness lesions were made in weight bearing and nonweight bearing areas of the radiocarpal, middle carpal and femoropatellar joints. The horses were euthanized in groups of two 1, 2.5, 4, 5 and 9 months later. Gross pathology, microradiography, and histopathology were used to evaluate qualitative aspects of articular repair. Computer assisted microdensitometry of safranin-O stained cartilage sections was used to quantitate cartilage matrix proteoglycan levels. Structural repair had occurred in most small defects at the end of nine months by a combination of matrix flow and extrinsic repair mechanisms. Elaboration of matrix proteoglycans was not complete at this time. Statistically better healing occurred in small weight bearing lesions, compared to large or nonweight bearing lesions. Synovial and perichondrial pannus interfered with healing of osteochondral defects that were adjacent to the cranial rim of the third carpal bone. Clinical and experimental experience suggests that these lesions are unlikely to heal, whereas similar lesions in the radiocarpal and femoropatellar joints had satisfactory outcomes. Observations made in this study support the use of early postoperative ambulation, passive flexion of operated joints, and recuperative periods of up to a year for large cartilage defects.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-2581923, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-3720093, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-4425033, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-453671, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-4894527, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-4922186, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-5011034, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-5047789, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-56336, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-6320835, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-6381426, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-6808869, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-7285461, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-7362684, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349393-7440603
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0830-9000
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
137-46
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effects of lesion size and location on equine articular cartilage repair.
pubmed:affiliation
Department of Clinical Studies, Ontario Veterinary College, University of Guelph.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't