Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-5-6
pubmed:abstractText
Experimental posterior uveitis was induced by the inoculation of retinal S-antigen into black hooded Lister rats. The time course of the disease was monitored by electroretinography (ERG), and the ERG changes were correlated with clinical signs and underlying pathological damage. The ERG became supernormal in the third week after inoculation, with some loss of temporal resolution (lowered ERG flicker fusion frequency), though the disease was not clinically manifest at this time and histological examination was normal. The ERG became subnormal after 21 days as clinical signs of disease began to appear. This subnormality was associated with focal photoreceptor necrosis, the degree of destruction being proportional to the reduction in the ERG. The ERG recovered with resolution of disease in most cases, though return to control values was uncommon. We suggest that the initial supernormal ERG reflects an underlying biochemical change mediated by the action of anti retinal S-antigen antibodies.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-1082724, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-13063906, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-13873687, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-14040380, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-2988124, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-334977, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-3651374, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-3967960, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-418545, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-4675001, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-4978009, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-5154270, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-5304456, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-5755786, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-6072241, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-727627, http://linkedlifedata.com/resource/pubmed/commentcorrection/3349019-7336605
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0007-1161
pubmed:author
pubmed:issnType
Print
pubmed:volume
72
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
88-96
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Experimental posterior uveitis. II. Electroretinographic studies.
pubmed:affiliation
Department of Immunology, UMDS, St Thomas's Campus, London.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't