Linked Life Data

3348436

Source:http://linkedlifedata.com/resource/pubmed/id/3348436

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3 Pt 2
pubmed:dateCreated
1988-4-19
pubmed:abstractText
The effects of exercise and food restriction on hemodynamic and metabolic characteristics of the heart during aging were studied in male, retired breeder, Fischer 344 rats. At the age of 10 mo they were divided into three groups: 1) sedentary and ad libitum fed (S); 2) sedentary and food restricted by alternate-day feeding (R); and 3) exercised 20 min/day on a treadmill and ad libitum fed (E). Isolated, perfused working hearts were analyzed at 10 (S only), 18, 24, and 30 mo. Groups E and R demonstrated significant improvements (P less than 0.01) at 18 mo for cardiac output (ml.min-1.g-1), pressure work (kg.m.min-1.g-1), and efficiency (%). These performance parameters declined (P less than 0.01) after 18 mo in all groups; however, at 24 mo, E maintained higher values (P less than 0.01) for these parameters than S or R. At 30 mo, all groups were similar. Levels of high-energy phosphate compounds or lactate release were not affected by age or treatment. An age-related increase (P less than 0.05) in left ventricular hexokinase activity was observed in all groups. Activities of rate-determining enzymes of Krebs cycle or content of cytochromes were not affected by age. We conclude from this metabolic profile that energy production is not impaired in the aged Fischer 344 rat heart.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
254
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
H599-608
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Cardiac energetics and performance of exercised and food-restricted rats during aging.
pubmed:affiliation
Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia 19104.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't