Linked Life Data

3347606

Source:http://linkedlifedata.com/resource/pubmed/id/3347606

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-4-19
pubmed:abstractText
Rats exposed to 25 or 300 ppm NH3 vapor for 5-15 days 6 hr daily showed dose-dependent blood ammonia after 5 days. Brain and blood glutamine were also increased at the same time in rats exposed to 300 ppm. The blood ammonia concentration of the exposed rats resumed control levels at 10 and 15 days while hepatic citrulline synthesis increased above that of the controls. The animals exposed to 300 ppm NH3 showed initially a slight acidosis. As circulating ammonia decreased, brain and blood glutamine returned to the control range. Our findings support the idea that ureagenesis is aimed mainly at the removal of NH+4 with only secondary and small effects on the acid-base balance.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
187
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
278-81
pubmed:dateRevised
2007-11-2
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Rat metabolic adaptation to ammonia inhalation.
pubmed:affiliation
Regional Institute of Occupational Health, Kuopio, Finland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't