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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0006267,
umls-concept:C0017968,
umls-concept:C0028959,
umls-concept:C0030705,
umls-concept:C0037812,
umls-concept:C0205195,
umls-concept:C0205225,
umls-concept:C0242209,
umls-concept:C0330390,
umls-concept:C0332307,
umls-concept:C0392762,
umls-concept:C0444669,
umls-concept:C0678594,
umls-concept:C0683278,
umls-concept:C0936012,
umls-concept:C1441547,
umls-concept:C1882074,
umls-concept:C2825492
|
| pubmed:issue |
3
|
| pubmed:dateCreated |
1988-4-11
|
| pubmed:abstractText |
A pool of neutral carbohydrate chains was prepared from respiratory mucins of a patient suffering from bronchiectasis. Fractionation by HPLC led to 35 smaller-size oligosaccharide-alditols; the structure of 16 oligosaccharide-alditols with core type 1 or type 2 has been established (Klein, A., Lamblin, G., Lhermitte, M., Roussel, P., Breg, J., Van Halbeek, H. & Vliegenthart, J.F.G., preceding paper in this journal). In this second part, we identified 19 oligosaccharide-alditols possessing core types 3 and 4. Nine of the structures (1, 5, 9, 6, 10b, 13, 19, 15b and 18.1) have been described previously to be present in cystic fibrosis mucins [Lamblin, G., Boersma, A., Lhermitte, M., Roussel, P., Mutsaers, J.G.H. M., Van Halbeek, H. & Vliegenthart, J.F.G. (1984) Eur. J. Biochem. 143, 227-234]. The remaining ten are new structures isolated from bronchial mucins; they are all extensions of the above-mentioned nine oligosaccharides. These compounds are octassaccharide-alditols containing the Y determinant together with the H determinant of either backbone-type 1 or 2, and partial structures thereof: (Formula: see text) and 21b, which is 23c without Fuc alpha(1----3), 18.2, which is 23c without any Fuc in the 6-branch, and 22b, which is 23c without Fuc in the 3-branch.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0014-2956
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
171
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
643-54
|
| pubmed:dateRevised |
2007-7-23
|
| pubmed:meshHeading |
pubmed-meshheading:3345750-Bronchiectasis,
pubmed-meshheading:3345750-Carbohydrate Conformation,
pubmed-meshheading:3345750-Carbohydrate Sequence,
pubmed-meshheading:3345750-Carbohydrates,
pubmed-meshheading:3345750-Chromatography, High Pressure Liquid,
pubmed-meshheading:3345750-Energy Transfer,
pubmed-meshheading:3345750-Glycoproteins,
pubmed-meshheading:3345750-Humans,
pubmed-meshheading:3345750-Hydrogen-Ion Concentration,
pubmed-meshheading:3345750-Magnetic Resonance Spectroscopy,
pubmed-meshheading:3345750-Molecular Sequence Data,
pubmed-meshheading:3345750-Mucus,
pubmed-meshheading:3345750-Oligosaccharides
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Primary structure of neutral oligosaccharides derived from respiratory-mucus glycoproteins of a patient suffering from bronchiectasis, determined by combination of 500-MHz 1H-NMR spectroscopy and quantitative sugar analysis. 2. Structure of 19 oligosaccharides having the GlcNAc beta(1----3)GalNAc-ol core (type 3) or the GlcNAc beta(1----3)[GlcNAc beta(1----6)]GalNAc-ol core (type 4).
|
| pubmed:affiliation |
Department of Bio-Organic Chemistry, University of Utrecht, The Netherlands.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|