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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1988-3-25
|
| pubmed:abstractText |
The phosphorylation of sperm specific histone H1 in the sea urchin Strongylocentrotus purpuratus occurs both in vivo and in vitro on a single serine site in the sequence Arg-Lys-Gly-Ser(P)-Ser-Asn-Ala-Arg. This is a preferred sequence for cAMP-dependent protein kinase. The in vitro phosphorylation is completely dependent on cAMP and is inhibited by the peptide protein kinase inhibitor. The protein kinase inhibitor H-8 blocks the in vivo phosphorylation of H1 without damaging motility, the acrosome reaction or the ability of sperm to fuse with and activate eggs.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0021-9258
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
263
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2750-5
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:3343229-Amino Acid Sequence,
pubmed-meshheading:3343229-Animals,
pubmed-meshheading:3343229-Binding Sites,
pubmed-meshheading:3343229-Histones,
pubmed-meshheading:3343229-Male,
pubmed-meshheading:3343229-Phosphorylation,
pubmed-meshheading:3343229-Protein Kinases,
pubmed-meshheading:3343229-Sea Urchins,
pubmed-meshheading:3343229-Species Specificity,
pubmed-meshheading:3343229-Spermatozoa
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
CAMP-dependent protein kinase of sea urchin sperm phosphorylates sperm histone H1 on a single site.
|
| pubmed:affiliation |
Marine Biology Research Division, Scripps Institution of Oceanography, University of California, San Diego, La Jolla 92093.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|