Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0005810,
umls-concept:C0015965,
umls-concept:C0017978,
umls-concept:C0032043,
umls-concept:C0043210,
umls-concept:C0229671,
umls-concept:C0332285,
umls-concept:C0486616,
umls-concept:C0599990,
umls-concept:C0600103,
umls-concept:C0936012,
umls-concept:C1425526,
umls-concept:C1705822,
umls-concept:C1858460
|
pubmed:issue |
1
|
pubmed:dateCreated |
1988-3-4
|
pubmed:abstractText |
To further define the molecules that may mediate spontaneous abortion due to maternal-fetal blood group incompatibility within the P blood group system, we have examined the fine specificities of maternal antibodies and the glycolipid antigens from the placenta of a P infant born to a Pk1 mother. Maternal antibodies obtained during therapeutic plasmapheresis were analyzed to determine their reactivities with placental glycolipid extracts on thin-layer plates. Second antibodies specific for IgM, IgG, and IgA revealed immunoglobulins of all of these classes strongly reactive with one major placental glycolipid that comigrates with globoside. GC/MS analysis confirmed that the major P-active pentaglycosylceramide of placenta has the same structure as that previously shown for the P antigen of red blood cells: GalNAc beta 1-3Gal alpha 1-4Gal beta 1-4Glc-Cer. Serum antibodies partially purified by affinity chromatography on globoside-octyl-Sepharose specifically recognize glycolipids that contain terminal GalNAc beta 1-3Gal . . . residues and also recognize the same sequence as an internal determinant in some, but not all, glycolipids with extended globoside core regions. Thus, in the blood group P incompatible fetus, the major P antigen present in placenta has the same carbohydrate structure as the P antigen present in fetal and adult erythrocytes and might be a target for the maternal immune system.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0003-9861
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
260
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
168-76
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:3341739-Adult,
pubmed-meshheading:3341739-Antibody Specificity,
pubmed-meshheading:3341739-Antigen-Antibody Reactions,
pubmed-meshheading:3341739-Blood Group Incompatibility,
pubmed-meshheading:3341739-Female,
pubmed-meshheading:3341739-Globosides,
pubmed-meshheading:3341739-Glycosphingolipids,
pubmed-meshheading:3341739-Humans,
pubmed-meshheading:3341739-Isoantibodies,
pubmed-meshheading:3341739-Placenta,
pubmed-meshheading:3341739-Pregnancy,
pubmed-meshheading:3341739-Pregnancy Complications, Hematologic
|
pubmed:year |
1988
|
pubmed:articleTitle |
The glycosphingolipid composition of the placenta of a blood group P fetus delivered by a blood group Pk1 woman and analysis of the anti-globoside antibodies found in maternal serum.
|
pubmed:affiliation |
Laboratory of Pathology, National Cancer Institute, Bethesda, Maryland 20892.
|
pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
|