Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-3-17
pubmed:abstractText
A glycoprotein, BCA-225 (Mr 225,000-250,000), has been identified in cells and spent medium of clone 11 T47D breast carcinoma cells by three murine monoclonal antibodies, CU18, CU26, and CU46. The antigen was localized in paraffin sections of 167/178 (94%) Bouin's-fixed human breast carcinoma tissues and few other carcinomas (1/8 lung [squamous], 4/4 uterine cervix) in an intracellular pattern, whereas an apical or glycocalyx distribution was seen in several normal tissues, benign lesions, and malignant tumors. Although the immunocytochemical staining patterns observed with these antibodies have many similarities to those described with other previously reported monoclonal antibodies, notable differences include the lack of reactivity of CU18, CU26, and CU46 with lactating mammary gland and with gastrointestinal malignancies. BCA-225 binds to wheat germ lectin, not to concanavalin A, but monoclonal antibody binding does not appear to involve the carbohydrate component of the molecule. The frequency of the immunocytochemical detection of BCA-225 in breast carcinomas and its restricted distribution in other human tissues suggest considerable clinical potential for this antigen and its corresponding monoclonal antibodies.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-206905, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-2579340, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-3881173, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-388439, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-393892, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-3965932, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-5432063, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-6094338, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-6163523, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-6176067, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-6180627, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-6206003, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-6273328, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-6330748, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-6349797, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-6352812, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-6353626, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-6365800, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-7063025, http://linkedlifedata.com/resource/pubmed/commentcorrection/3341450-80418
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0002-9440
pubmed:author
pubmed:issnType
Print
pubmed:volume
130
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
305-14
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Immunocytochemical distribution of a breast carcinoma associated glycoprotein identified by monoclonal antibodies.
pubmed:affiliation
Department of Pathology, College of Physicians and Surgeons, Columbia University, New York, New York.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't