| pubmed-article:3340213 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3340213 | lifeskim:mentions | umls-concept:C0001511 | lld:lifeskim |
| pubmed-article:3340213 | lifeskim:mentions | umls-concept:C0282587 | lld:lifeskim |
| pubmed-article:3340213 | lifeskim:mentions | umls-concept:C0079717 | lld:lifeskim |
| pubmed-article:3340213 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:3340213 | lifeskim:mentions | umls-concept:C1322652 | lld:lifeskim |
| pubmed-article:3340213 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:3340213 | lifeskim:mentions | umls-concept:C0598077 | lld:lifeskim |
| pubmed-article:3340213 | pubmed:issue | 6157 | lld:pubmed |
| pubmed-article:3340213 | pubmed:dateCreated | 1988-3-23 | lld:pubmed |
| pubmed-article:3340213 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3340213 | pubmed:abstractText | Antigen-specific cell contacts in the immune system are strengthened by antigen-nonspecific interactions, mediated in part by lymphocyte-function associated (LFA) antigens. The LFA-1 antigen is widely expressed on cells of haematopoietic origin and is a major receptor of T cells, B cells and granulocytes. LFA-1 mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by natural killer cells and granulocytes. Recently, ICAM-1 (intercellular adhesion molecule-1) has been defined as a ligand for LFA-1. Monoclonal antibodies to ICAM-1 block T lymphocyte adhesion to fibroblasts and endothelial cells and disrupt the interaction between cytotoxic T cells and target cells. In addition, purified ICAM-1 reconstituted into artificial membranes binds LFA-1+ cells. ICAM-1 is found on leukocytes, fibroblasts, epithelial cells and endothelial cells and its expression is regulated by inflammatory cytokines. LFA-1 has been placed in the integrin family of cell surface receptors by virtue of the high sequence similarity between the LFA-1 and integrin beta chains. The adhesion ligands of the integrin family are glycoproteins bearing the Arg-Gly-Asp (RGD) sequence motif, for example, fibronectin, fibrinogen, vitronectin and von Willebrand factor. Here we show that a complementary DNA clone ICAM-1 contains no RGD motifs, but instead is homologous to the neural cell adhesion molecule NCAM. | lld:pubmed |
| pubmed-article:3340213 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3340213 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3340213 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3340213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3340213 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3340213 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3340213 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3340213 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:3340213 | pubmed:author | pubmed-author:SimmonsDD | lld:pubmed |
| pubmed-article:3340213 | pubmed:author | pubmed-author:SeelJJ | lld:pubmed |
| pubmed-article:3340213 | pubmed:author | pubmed-author:MakgobaM WMW | lld:pubmed |
| pubmed-article:3340213 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3340213 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:3340213 | pubmed:volume | 331 | lld:pubmed |
| pubmed-article:3340213 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3340213 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3340213 | pubmed:pagination | 624-7 | lld:pubmed |
| pubmed-article:3340213 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3340213 | pubmed:meshHeading | pubmed-meshheading:3340213-... | lld:pubmed |
| pubmed-article:3340213 | pubmed:meshHeading | pubmed-meshheading:3340213-... | lld:pubmed |
| pubmed-article:3340213 | pubmed:meshHeading | pubmed-meshheading:3340213-... | lld:pubmed |
| pubmed-article:3340213 | pubmed:meshHeading | pubmed-meshheading:3340213-... | lld:pubmed |
| pubmed-article:3340213 | pubmed:meshHeading | pubmed-meshheading:3340213-... | lld:pubmed |
| pubmed-article:3340213 | pubmed:meshHeading | pubmed-meshheading:3340213-... | lld:pubmed |
| pubmed-article:3340213 | pubmed:meshHeading | pubmed-meshheading:3340213-... | lld:pubmed |
| pubmed-article:3340213 | pubmed:meshHeading | pubmed-meshheading:3340213-... | lld:pubmed |
| pubmed-article:3340213 | pubmed:meshHeading | pubmed-meshheading:3340213-... | lld:pubmed |
| pubmed-article:3340213 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3340213 | pubmed:articleTitle | ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM. | lld:pubmed |
| pubmed-article:3340213 | pubmed:affiliation | Department of Molecular Biology, Harvard Medical School, Massachusetts General Hospital, Boston 02114. | lld:pubmed |
| pubmed-article:3340213 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3340213 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3340213 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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