Linked Life Data

3338430

Source:http://linkedlifedata.com/resource/pubmed/id/3338430

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-3-17
pubmed:abstractText
Lacinilene C methyl ether (LCME) is a constituent of the cotton plant and has been implicated as a causative agent of byssinosis. The effect of synthetic LCME on the behavior of isolated strips of canine tracheal smooth muscle (TSM) was examined in tissue bath experiments. LCME (0.64-6.6 x 10(-4) M) caused slowly developing but strong and sustained contractions of TSM strips. Blockade of acetycholine, 5-hydroxytryptamine (5-HT), and histamine H1 receptors with atropine, methysergide, and pyrilamine, respectively, had no effect on constrictions induced by LCME. In contrast, the calcium channel antagonist, verapamil, significantly reduced the response to LCME. Moreover, addition of the beta receptor agonist, isoproterenol, at the peak of LCME-induced contractions relaxed tissues in a concentration-dependent manner. We conclude that LCME elicits contraction of TSM by enhancing the movement of calcium through potential-dependent channels of smooth muscle cell membranes. This mechanism of action does not require activation of specific membrane receptors for acetylcholine, 5-HT, and histamine.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0013-9351
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
118-26
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Lacinilene C methyl ether (LCME) constricts tracheal smooth muscle.
pubmed:affiliation
Department of Pediatrics, State University of New York, Buffalo 14214.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't