| pubmed-article:3338305 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3338305 | lifeskim:mentions | umls-concept:C0001080 | lld:lifeskim |
| pubmed-article:3338305 | lifeskim:mentions | umls-concept:C0205076 | lld:lifeskim |
| pubmed-article:3338305 | lifeskim:mentions | umls-concept:C0037981 | lld:lifeskim |
| pubmed-article:3338305 | lifeskim:mentions | umls-concept:C0439534 | lld:lifeskim |
| pubmed-article:3338305 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3338305 | pubmed:dateCreated | 1988-3-10 | lld:pubmed |
| pubmed-article:3338305 | pubmed:abstractText | Standard values for pulmonary function in short-limbed dwarfism are not available. Therefore, chest diameters and expiratory spirograms were measured in 58 female and 44 male subjects between 7 and 60 years of age with achondroplasia, the most common form of dwarfism. Standing height in adults was 49.6 +/- 3.2 (SD) inches with a sitting/standing height ratio of 0.66 (normal 0.52-0.53). Despite extremely short stature, only AP chest diameters in males were smaller than control subjects of similar age. The following equations were derived for forced vital capacity (FVC): males (under 25 years), FVC(L) = -3.56 + 0.162 X sitting height (in) + 0.067 X age (yrs); males (over 25 years), FVC(L) = -0.73 + 0.162 X sitting height (in) -0.047 X age (yrs); females (under 20 years), FVC(L) = -3.56 + 0.150 X sitting height (in) + 0.067 X age (yrs); females (over 20 years), FVC(L) = -1.92 + 0.150 X sitting height (in) -0.016 X age (years). Similar prediction equations were derived for FEV1 and FEF25-75%: FEV1/FVC % was 84.2 (+/- 6.5) for females and 88.0 (+/- 6.5) for males. We also compared the observed FVC measurements to values calculated using standing heights derived from the subject's sitting height, assuming a normal body proportion. The observed vital capacity in achondroplasia was only 67.6 (+/- 19.2) percent of that predicted for normally proportioned females and 72.4 (+/- 13.6) percent for males, suggesting reduced vital capacity in achondroplasia, due to reduced chest wall compliance or abnormal lung growth. | lld:pubmed |
| pubmed-article:3338305 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3338305 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3338305 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3338305 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3338305 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3338305 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:3338305 | pubmed:issn | 0012-3692 | lld:pubmed |
| pubmed-article:3338305 | pubmed:author | pubmed-author:WiseR ARA | lld:pubmed |
| pubmed-article:3338305 | pubmed:author | pubmed-author:MurphyE AEA | lld:pubmed |
| pubmed-article:3338305 | pubmed:author | pubmed-author:PyeritzR ERE | lld:pubmed |
| pubmed-article:3338305 | pubmed:author | pubmed-author:StokesD CDC | lld:pubmed |
| pubmed-article:3338305 | pubmed:author | pubmed-author:FaircloughDD | lld:pubmed |
| pubmed-article:3338305 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3338305 | pubmed:volume | 93 | lld:pubmed |
| pubmed-article:3338305 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3338305 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3338305 | pubmed:pagination | 364-9 | lld:pubmed |
| pubmed-article:3338305 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
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| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
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| pubmed-article:3338305 | pubmed:meshHeading | pubmed-meshheading:3338305-... | lld:pubmed |
| pubmed-article:3338305 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3338305 | pubmed:articleTitle | Spirometry and chest wall dimensions in achondroplasia. | lld:pubmed |
| pubmed-article:3338305 | pubmed:affiliation | Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD. | lld:pubmed |
| pubmed-article:3338305 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3338305 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3338305 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3338305 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3338305 | lld:pubmed |
