Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1988-3-10
|
| pubmed:abstractText |
Standard values for pulmonary function in short-limbed dwarfism are not available. Therefore, chest diameters and expiratory spirograms were measured in 58 female and 44 male subjects between 7 and 60 years of age with achondroplasia, the most common form of dwarfism. Standing height in adults was 49.6 +/- 3.2 (SD) inches with a sitting/standing height ratio of 0.66 (normal 0.52-0.53). Despite extremely short stature, only AP chest diameters in males were smaller than control subjects of similar age. The following equations were derived for forced vital capacity (FVC): males (under 25 years), FVC(L) = -3.56 + 0.162 X sitting height (in) + 0.067 X age (yrs); males (over 25 years), FVC(L) = -0.73 + 0.162 X sitting height (in) -0.047 X age (yrs); females (under 20 years), FVC(L) = -3.56 + 0.150 X sitting height (in) + 0.067 X age (yrs); females (over 20 years), FVC(L) = -1.92 + 0.150 X sitting height (in) -0.016 X age (years). Similar prediction equations were derived for FEV1 and FEF25-75%: FEV1/FVC % was 84.2 (+/- 6.5) for females and 88.0 (+/- 6.5) for males. We also compared the observed FVC measurements to values calculated using standing heights derived from the subject's sitting height, assuming a normal body proportion. The observed vital capacity in achondroplasia was only 67.6 (+/- 19.2) percent of that predicted for normally proportioned females and 72.4 (+/- 13.6) percent for males, suggesting reduced vital capacity in achondroplasia, due to reduced chest wall compliance or abnormal lung growth.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0012-3692
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
93
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
364-9
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3338305-Achondroplasia,
pubmed-meshheading:3338305-Adolescent,
pubmed-meshheading:3338305-Adult,
pubmed-meshheading:3338305-Child,
pubmed-meshheading:3338305-Female,
pubmed-meshheading:3338305-Forced Expiratory Flow Rates,
pubmed-meshheading:3338305-Forced Expiratory Volume,
pubmed-meshheading:3338305-Humans,
pubmed-meshheading:3338305-Lung,
pubmed-meshheading:3338305-Male,
pubmed-meshheading:3338305-Middle Aged,
pubmed-meshheading:3338305-Reference Values,
pubmed-meshheading:3338305-Spirometry,
pubmed-meshheading:3338305-Thorax,
pubmed-meshheading:3338305-Vital Capacity
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Spirometry and chest wall dimensions in achondroplasia.
|
| pubmed:affiliation |
Department of Pediatrics, Johns Hopkins Medical Institutions, Baltimore, MD.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|