Linked Life Data

3337267

Source:http://linkedlifedata.com/resource/pubmed/id/3337267

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Pt 2
pubmed:dateCreated
1988-2-25
pubmed:abstractText
Based on consideration of rat plasma Ca and 45Ca concentrations, we analyze the circadian behavior of Ca metabolism of the rat as the temporal expression of a self-organized system. We present a self-oscillatory model M for rat Ca metabolism based on a compartmental formalism, which includes a second-order autocatalytic process. M describes the entire mass of Ca as made up of eight compartments and predicts a distinction between 1) the amount of Ca deposited in zones of rapid bone growth and reutilized during bone maturation and 2) the amount of Ca in mature bone subdivided into four compartments. Two of these compartments, largely self-oscillating, may represent Ca-P associations at bone liquid/solid interface and are subject to osteoblast-osteocyte control. The other two compartments can be thought of as made up of a large expanding pool of hydroxyapatite (HA) crystals, which are largely unavailable as such, and a small pool or more available HA crystals. Bone Ca influx and rhythmic efflux play a major role in the regulation of Ca in extracellular fluid but must be dissociated from bone accretion and resorption. Application to Ca deficiency was analyzed. Conceptual consequences of the connection of Ca metabolism to a self-regulated system are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-9513
pubmed:author
pubmed:issnType
Print
pubmed:volume
254
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
R134-49
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Calcium metabolism in the rat: a temporal self-organized model.
pubmed:affiliation
UA 163, Centre National de la Recherche Scientifique, CHU Saint Antoine, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't