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rdf:type |
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lifeskim:mentions |
umls-concept:C0001041,
umls-concept:C0003385,
umls-concept:C0019564,
umls-concept:C0030685,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1519355,
umls-concept:C1707391,
umls-concept:C1963578
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pubmed:issue |
1
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pubmed:dateCreated |
1988-2-24
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pubmed:abstractText |
A number of cholinergic muscarinic (M) agonists and antagonists were studied for their ability to enhance tritiated acetylcholine ([3H]ACh) release from electrically field-stimulated rat hippocampal slices. A Ca++-free medium and carbachol, but not nicotine, inhibited [3H]ACh release. Atropine, methylatropine and dexetimide produced concentration-dependent increases in [3H]ACh release to a maximum of about 50% above control. Aprophen and benactyzine produced a maximal response 25 to 35% above control. The selective M1 antagonist pirenzepine had the least effect on [3H]ACh release. Of the nonspecific M1-M2 antagonists studied, benactyzine produced the least amount of [3H]ACh release. The order of potency of the M antagonists in promoting a 15% increase in [3H]ACh release was aprophen greater than benactyzine greater than methylatropine greater than dexetimide greater than pirenzepine greater than atropine. However, the order of promoting maximal release of [3H]ACh was atropine greater than dexetimide greater than methylatropine greater than aprophen greater than benactyzine greater than pirenzepine.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Atropine,
http://linkedlifedata.com/resource/pubmed/chemical/Atropine Derivatives,
http://linkedlifedata.com/resource/pubmed/chemical/Benactyzine,
http://linkedlifedata.com/resource/pubmed/chemical/Carbachol,
http://linkedlifedata.com/resource/pubmed/chemical/Dexetimide,
http://linkedlifedata.com/resource/pubmed/chemical/Hemicholinium 3,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylpropionates,
http://linkedlifedata.com/resource/pubmed/chemical/Quinuclidinyl Benzilate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Muscarinic,
http://linkedlifedata.com/resource/pubmed/chemical/aprofen,
http://linkedlifedata.com/resource/pubmed/chemical/methylatropine
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-3565
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
244
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
213-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3335998-Acetylcholine,
pubmed-meshheading:3335998-Animals,
pubmed-meshheading:3335998-Atropine,
pubmed-meshheading:3335998-Atropine Derivatives,
pubmed-meshheading:3335998-Benactyzine,
pubmed-meshheading:3335998-Carbachol,
pubmed-meshheading:3335998-Dexetimide,
pubmed-meshheading:3335998-Dose-Response Relationship, Drug,
pubmed-meshheading:3335998-Electric Stimulation,
pubmed-meshheading:3335998-Hemicholinium 3,
pubmed-meshheading:3335998-Hippocampus,
pubmed-meshheading:3335998-Male,
pubmed-meshheading:3335998-Nicotine,
pubmed-meshheading:3335998-Phenylpropionates,
pubmed-meshheading:3335998-Quinuclidinyl Benzilate,
pubmed-meshheading:3335998-Rats,
pubmed-meshheading:3335998-Rats, Inbred Strains,
pubmed-meshheading:3335998-Receptors, Muscarinic
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pubmed:year |
1988
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pubmed:articleTitle |
Effects of selected muscarinic cholinergic antagonists on [3H]acetylcholine release from rat hippocampal slices.
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pubmed:affiliation |
Department of Pharmacology, University of Michigan, Ann Arbor.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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