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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1988-2-23
|
| pubmed:abstractText |
A synergistic increase in the cytotoxic effects of recombinant human tumor necrosis factor (rH-TNF) and hyperthermia was demonstrated both in vitro and in vivo. The cytotoxicity of rH-TNF against L-M cells in incubation for 12 h at 38.5 and 40 degrees C based on the concentration necessary for 50% cytotoxicity was, respectively, 125 and more than 500 times as high as in similar incubation at 37 degrees C. As observed 18 days after implantation of Meth-A fibrosarcoma cells in mice, single i.v. administration of rH-TNF at 1000 units/mouse resulted in complete cures in five mice when performed in combination with hyperthermia (40 degrees C), whereas rH-TNF alone in the same dose resulted in 27.1% inhibition of tumor growth and hyperthermia alone had no appreciable effect on tumor growth. The i.v. administration of rH-TNF three times at 100 or 300 units/mouse together with hyperthermia (40 degrees C) resulted in 41.2 and 89.0% tumor growth inhibition, respectively; similar administration without hyperthermia appeared to have little or no appreciable effect on tumor growth. The results suggest that combination therapy including rH-TNF and hyperthermia may be of value in the treatment of malignancy in human patients.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
48
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
650-3
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3335027-Animals,
pubmed-meshheading:3335027-Cell Survival,
pubmed-meshheading:3335027-Drug Administration Schedule,
pubmed-meshheading:3335027-Hyperthermia, Induced,
pubmed-meshheading:3335027-Mice,
pubmed-meshheading:3335027-Neoplasms, Experimental,
pubmed-meshheading:3335027-Time Factors,
pubmed-meshheading:3335027-Tumor Cells, Cultured,
pubmed-meshheading:3335027-Tumor Necrosis Factor-alpha
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Synergistic cytotoxic and antitumor effects of recombinant human tumor necrosis factor and hyperthermia.
|
| pubmed:affiliation |
Department of Internal Medicine, Sapporo Medical College, Japan.
|
| pubmed:publicationType |
Journal Article
|