3332138

Source:http://linkedlifedata.com/resource/pubmed/id/3332138

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0023467, umls-concept:C0030705, umls-concept:C0194037, umls-concept:C0205178, umls-concept:C1707455
pubmed:issue	3
pubmed:dateCreated	1988-11-15
pubmed:abstractText	Forty-two patients with acute leukaemia were treated with autologous bone marrow transplantation (ABMT) using a combination chemotherapy protocol for bone marrow ablation. The response to high-dose chemotherapy and ABMT and its associated morbidity and mortality have been compared in 24 patients with acute myeloid leukaemia (AML) and 18 patients with acute lymphoblastic leukaemia (ALL). In 16 patients with AML treated with ABMT during first complete remission (CR), ten patients (62.5%) remain in unmaintained remission; median follow up is 32 months. In eight patients with ALL treated in first CR, only one remains in remission 32 months post-ABMT, with three patients dying non-leukaemic deaths. Fourteen of 18 patients (AML and ALL) treated after first remission have died of recurrent leukaemia, two died non-leukaemic deaths and two remain well 31 and 55 months post-ABMT; both have ALL. The length of hospital stay and the amount of blood product support were similar in both groups. Haematological recovery post-ABMT was delayed in patients with AML compared to patients with ALL but this difference was not significant. Rapidly progressive lung infection was thought to be the cause of four early deaths (4/18) in patients with ALL but none in patients with AML. Severe gram-negative infections were significantly more common in patients with AML.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/8702459
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0268-3369
pubmed:author	pubmed-author:AndersonC CCC, pubmed-author:BoughtonB JBJ, pubmed-author:CawleyJ CJC, pubmed-author:FranklinI MIM, pubmed-author:GoldstoneA HAH, pubmed-author:JonesH MHM, pubmed-author:LinchD CDC, pubmed-author:RichardsJ DJD
pubmed:issnType	Print
pubmed:volume	1
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	271-9
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:3332138-Adolescent, pubmed-meshheading:3332138-Adult, pubmed-meshheading:3332138-Blood Cell Count, pubmed-meshheading:3332138-Blood Transfusion, pubmed-meshheading:3332138-Bone Marrow Transplantation, pubmed-meshheading:3332138-Child, pubmed-meshheading:3332138-Female, pubmed-meshheading:3332138-Humans, pubmed-meshheading:3332138-Infection, pubmed-meshheading:3332138-Length of Stay, pubmed-meshheading:3332138-Leukemia, Myeloid, Acute, pubmed-meshheading:3332138-Male, pubmed-meshheading:3332138-Middle Aged, pubmed-meshheading:3332138-Postoperative Complications, pubmed-meshheading:3332138-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:3332138-Recurrence, pubmed-meshheading:3332138-Remission Induction, pubmed-meshheading:3332138-Transplantation, Autologous
pubmed:year	1987
pubmed:articleTitle	Autologous bone marrow transplantation for patients with acute myeloid leukaemia and acute lymphoblastic leukaemia--a comparison.
pubmed:affiliation	Department of Haematology, University College Hospital, London, UK.
pubmed:publicationType	Journal Article, Comparative Study