Linked Life Data

3330602

Source:http://linkedlifedata.com/resource/pubmed/id/3330602

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
836
pubmed:dateCreated
1988-7-28
pubmed:abstractText
The efficacy and patient acceptance of transdermal clonidine applied once a week were assessed in 62 mild hypertensives previously controlled on a diuretic and/or beta-blocker in a general practice setting involving 18 general practitioners. Patients underwent 3-5 week wash-out period and those patients whose mean seated diastolic blood pressure returned to levels between 91-105 mmHg or increased by greater than 10 mmHg above the initial value, were titrated with transdermal clonidine (Catapres-TTS-1, 2, or 3) and maintained on the optimal dose for 3 months with monthly check-ups. Satisfactory response of blood pressure to levels below 90 mmHg or greater than 10 mmHg reduction from the wash-out level was obtained in 85% of patients who completed the titration phase; nine patients failed to achieve a satisfactory blood pressure control. There was no significant difference in blood pressure response between previous therapy and transdermal clonidine treatment. Systemic side effects were minimal. Eight patients withdrew because of local allergic contact dermatitis. This study confirms that transdermal clonidine is at least as effective in reducing blood pressure as diuretic and/or beta-blocker therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0028-8446
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
711-3
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Transdermal clonidine (Catapres-TTS) monotherapy in the management of mild hypertension in general practice.
pubmed:affiliation
Napier Hospital.
pubmed:publicationType
Journal Article, Clinical Trial