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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3-4
|
| pubmed:dateCreated |
1988-5-27
|
| pubmed:abstractText |
delta 9-Tetrahydrocannabinol, cannabidiol, cannabidiolic acid, tetrahydrocannabidiolic acid, cannabispirol, acetylcannabispirol, cannabispirone, and cannabispirenone in a low concentration did not affect the adhesion of Escherichia coli on cultured HEp-2 cells. Cannabinoids at 10(-6) M increased the chemiluminescence of human polymorphonuclear leukocytes, while the cannabispiro compounds failed to enhance the oxidative burst of leukocytes. In lymphocyte and granulocyte function tests (E- and EA-rosette formation, blast transformation of T-lymphocytes in the presence of phytohaemagglutinin and concanavalin-A, ADCC and phagocytosis) all compounds displayed immunosuppressive effect at 1.5 X 10(-5) M. Tetrahydrocannabidiolic acid exerted the weakest immunosuppression on human leukocyte functions.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0231-4622
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
34
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
233-40
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3329437-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:3329437-Bacterial Adhesion,
pubmed-meshheading:3329437-Cannabinoids,
pubmed-meshheading:3329437-Cell Line,
pubmed-meshheading:3329437-Chemical Phenomena,
pubmed-meshheading:3329437-Chemistry,
pubmed-meshheading:3329437-Escherichia coli,
pubmed-meshheading:3329437-Granulocytes,
pubmed-meshheading:3329437-Humans,
pubmed-meshheading:3329437-Immunosuppression,
pubmed-meshheading:3329437-Leukocytes,
pubmed-meshheading:3329437-Luminescent Measurements,
pubmed-meshheading:3329437-Lymphocyte Activation,
pubmed-meshheading:3329437-Lymphocytes,
pubmed-meshheading:3329437-Neutrophils,
pubmed-meshheading:3329437-Phagocytosis,
pubmed-meshheading:3329437-Rosette Formation,
pubmed-meshheading:3329437-Spiro Compounds
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
The effects of cannabinoids and cannabispiro compounds on Escherichia coli adhesion to tissue culture cells and on leukocyte functions in vitro.
|
| pubmed:affiliation |
Institute of Microbiology, University Medical School, Szeged, Hungary.
|
| pubmed:publicationType |
Journal Article
|