Linked Life Data

3327692

Source:http://linkedlifedata.com/resource/pubmed/id/3327692

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-5-2
pubmed:abstractText
In this study, the kidney analog of the erythrocyte anion exchanger, band 3, served as the first example of an anion translocating membrane protein in a nucleated cell type to be localized at the ultrastructural level. Kidney band 3 was found to be confined to the basolateral membrane of the intercalated cells in the human collecting duct. The immunogold label displayed a striking non-uniform distribution along the basolateral plasma membrane with a preferential concentration at pleated areas of the membrane surface. The pleated portions are suggested to represent specialized subdomains to which the band 3 analog might be restricted by linkage via ankyrin to the spectrin-based membrane cytoskeleton. The immunolabel did not extend apically to the level of the zonula adherens and zonula occludens indicating that tight junctions might not be important for maintaining the polarized distribution of this integral membrane protein. Association of antibody label with the rough endoplasmic reticulum and other types of cytoplasmic membranes indicate pathways in the biosynthesis and degradation of this anion exchanger.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0171-9335
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
107-15
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Restriction of the human kidney band 3-like anion exchanger to specialized subdomains of the basolateral plasma membrane of intercalated cells.
pubmed:affiliation
Department of Anatomy and Cell Biology, University of Marburg, Federal Republic of Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't