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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1988-3-24
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pubmed:abstractText |
Suramin administration inhibits virus replication and produces impaired immunoregulation. Delayed type hypersensitivity (DTH)-reaction was inhibited by Suramin (200 mg/kg, i.p.) injection in guinea-pigs immunized with BCG vaccine. Suramin-inhibited DTH-reaction was restored to normal level after 4 days of treatment with thymopoietin 32-34 (TP 3) and TP5 (1 mg/kg, i.p.), TP3 greater than TP5. TP3 produced the strongest restoration when applied together with Suramin, but a single treatment with TP3 or TP5 oligopeptide inhibited the development of DTH-reaction. TP3 with Suramin treatment might be advantageous to eliminate defective side effects of Suramin on immune system and TP3 with indirect inducing action on IL-2, IFN-gamma production may be useful in therapy of AIDS patients.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0882-0139
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
275-9
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3323037-Animals,
pubmed-meshheading:3323037-Guinea Pigs,
pubmed-meshheading:3323037-Hypersensitivity, Delayed,
pubmed-meshheading:3323037-Immunity, Cellular,
pubmed-meshheading:3323037-Oligopeptides,
pubmed-meshheading:3323037-Peptide Fragments,
pubmed-meshheading:3323037-Suramin,
pubmed-meshheading:3323037-Thymopentin,
pubmed-meshheading:3323037-Thymopoietins,
pubmed-meshheading:3323037-Thymus Hormones
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pubmed:year |
1987
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pubmed:articleTitle |
The effect of thymopoietin 32-34 (TP3) on suramin-induced inhibition on delayed type hypersensitivity in guinea pigs.
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pubmed:affiliation |
Chemical Works of Gedeon Richter Ltd., Pharmacological Research Centre, Budapest, Hungary.
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pubmed:publicationType |
Journal Article
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