Linked Life Data

3322471

Source:http://linkedlifedata.com/resource/pubmed/id/3322471

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1988-3-2
pubmed:abstractText
A histochemical study of lectin binding was performed to assess staining with lectins and, therefore, the expression of complex carbohydrates in human neoplastic urothelium. Forty-seven patients with transitional cell carcinoma of the bladder and six controls were studied. Cryostat sections were stained with a panel of 10 biotinylated lectins by means of the avidin-biotin-peroxidase technique. Sixteen tumours were also studied after conventional formalin fixation and paraffin embedding. In general, staining by lectins of tumours was more intense than staining of control urothelium and staining of tumours invading bladder muscle was greater than that of superficial tumours (both P less than 0.001). A small but statistically significant diminution of staining was observed after formalin fixation and paraffin embedding (P less than 0.05). Four lectins--Bandeiraea simplicifolia (P less than 0.01), Vicia villosa (P less than 0.01), peanut agglutinin (P less than 0.001) and soyabean agglutinin (P less than 0.001) stained invasive tumours more frequently than superficial tumours in frozen sections. Thus, increased binding of certain lectins was found in human transitional cell tumours and correlated with muscle invasion and poor differentiation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0007-1331
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
399-404
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Histochemical study of lectin binding in neoplastic and non-neoplastic urothelium.
pubmed:affiliation
Department of Urology, Freeman Hospital, Newcastle upon Tyne.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't