Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4-5
pubmed:dateCreated
1977-10-28
pubmed:abstractText
Evidence is reviewed that supports the concept of extrinsic stem cell colonization of inductive micro-environments for B-cell formation in the bursa of Fabricius of chickens and foetal liver of mammals. In these organs, the first distinctive marker of B-lineage differentiation (readily detectable immunoglobulin) is synthesized and displayed on cells which have extensive proliferative and differentiative capacity. The degree of commitment of these cells to the synthesis of trace or large quantities of immunoglobulin of the respective major classes when they colonize peripheral lymphoid tissues and the role of antigen in this process are considered.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-4910
pubmed:author
pubmed:issnType
Print
pubmed:volume
128C
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
753-61
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Functionally distinct stages in B-lymphocyte maturation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review