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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
1988-2-10
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pubmed:abstractText |
The role of antibodies of CD15 as diagnostic markers of Hodgkin's disease was assessed from a review of the literature. A total of 571 cases of Hodgkin's disease and 386 cases of non-Hodgkin's lymphoma were included. The sensitivity of CD15 in detecting cases of Hodgkin's disease was 80% or 91% if cases of lymphocyte predominant Hodgkin's disease were excluded. The specificity of CD15 was only 80.6%, or in other words, 19.4% of cases of non-Hodgkin's lymphoma were CD15 positive. In an ideal test both the sensitivity and specificity would be 100% and if the test performance were no better than chance then they would both be 50%. It is concluded that CD15 immunostaining cannot be regarded as a sensitive or specific marker of Hodgkin's disease. Application of this formal method of analysis to other immunohistological reagents and panels of antibodies is discussed.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-2426430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-2428238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-2434403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-2579718,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-2579887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-2941082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-2946220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-2995454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3079637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3085509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3085523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3092632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3155642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3158209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3462119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3514684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3516118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3529924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3540243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3540670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3546052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3754087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3760237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3840354,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3864794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3876124,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3881481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3887932,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3907362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3908491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3942963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3957243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-3970138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-4031096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-4118369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-4137045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-4880413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-5468029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-5513500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-6164473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-6179666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-6183295,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-6268975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-6368356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-6370286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-6395656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-6452080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-6677560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-6741873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-6798919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-6877322,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-692598,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-7074635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3320093-7160151
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9746
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1298-304
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1987
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pubmed:articleTitle |
Value of CD15 immunostaining in diagnosing Hodgkin's disease: a review of published literature.
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pubmed:affiliation |
Department of Histopathology, St Bartholomew's Hospital, London.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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