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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4830
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pubmed:dateCreated |
1987-12-23
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18481,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18482,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18483,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18484,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18485,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18486,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18487,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18488,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18489,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18490,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18491,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18492,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18493,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18494,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18495,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18496,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18497,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M18498
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pubmed:abstractText |
The repertoire of antibody variable (V) regions has been subject to evolutionary selection, affecting both the diversity of V region genes in the germline and their expression in the B lymphocyte population and its subsets. In ontogeny, contact with an antigen leads to the expansion of B cells expressing antibodies complementary to it. In a defined phase of B cell differentiation, new sets of V regions are generated from the existing repertoire through somatic hypermutation. Cells carrying advantageous antibody mutants are selected into the memory compartment and produce a stable secondary response upon reexposure to the antigen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
238
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1088-94
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:3317826-Animals,
pubmed-meshheading:3317826-Antibodies,
pubmed-meshheading:3317826-Antibody Diversity,
pubmed-meshheading:3317826-B-Lymphocytes,
pubmed-meshheading:3317826-Biological Evolution,
pubmed-meshheading:3317826-Genes, Immunoglobulin,
pubmed-meshheading:3317826-Genes, Switch,
pubmed-meshheading:3317826-Immunity,
pubmed-meshheading:3317826-Immunoglobulin Isotypes,
pubmed-meshheading:3317826-Immunoglobulin Variable Region,
pubmed-meshheading:3317826-Mice,
pubmed-meshheading:3317826-Mutation,
pubmed-meshheading:3317826-Selection, Genetic
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pubmed:year |
1987
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pubmed:articleTitle |
Evolutionary and somatic selection of the antibody repertoire in the mouse.
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pubmed:affiliation |
Institute for Genetics, University of Cologne, Köln, FRG.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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