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| pubmed-article:3316982 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:3316982 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:3316982 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:3316982 | lifeskim:mentions | umls-concept:C0032136 | lld:lifeskim |
| pubmed-article:3316982 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:3316982 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:3316982 | lifeskim:mentions | umls-concept:C0439201 | lld:lifeskim |
| pubmed-article:3316982 | lifeskim:mentions | umls-concept:C1704222 | lld:lifeskim |
| pubmed-article:3316982 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:3316982 | pubmed:dateCreated | 1988-1-19 | lld:pubmed |
| pubmed-article:3316982 | pubmed:abstractText | We have examined the replication and segregation of the Saccharomyces cerevisiae 2 microns circle. The amplification of the plasmid at low copy numbers requires site-specific recombination between the 2 microns inverted repeat sequences catalyzed by the plasmid-encoded FLP gene. No other 2 microns gene products are required. The overexpression of FLP in a strain carrying endogenous 2 microns leads to uncontrolled plasmid replication, longer cell cycles, and cell death. Two different assays show that the level of Flp activity decreases with increasing 2 microns copy number. This regulation requires the products of the REP1 and REP2 genes. These gene products also act together to ensure that 2 microns molecules are randomly segregated between mother and daughter cells at cell division. | lld:pubmed |
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| pubmed-article:3316982 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3316982 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3316982 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3316982 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3316982 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3316982 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:3316982 | pubmed:author | pubmed-author:MurrayA WAW | lld:pubmed |
| pubmed-article:3316982 | pubmed:author | pubmed-author:SzostakJ WJW | lld:pubmed |
| pubmed-article:3316982 | pubmed:author | pubmed-author:ReynoldsA EAE | lld:pubmed |
| pubmed-article:3316982 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3316982 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:3316982 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3316982 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3316982 | pubmed:pagination | 3566-73 | lld:pubmed |
| pubmed-article:3316982 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3316982 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3316982 | pubmed:articleTitle | Roles of the 2 microns gene products in stable maintenance of the 2 microns plasmid of Saccharomyces cerevisiae. | lld:pubmed |
| pubmed-article:3316982 | pubmed:affiliation | Department of Molecular Biology, Massachusetts General Hospital, Boston 02114. | lld:pubmed |
| pubmed-article:3316982 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3316982 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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