Linked Life Data

3315786

Source:http://linkedlifedata.com/resource/pubmed/id/3315786

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1988-1-12
pubmed:abstractText
We evaluated insulin secretion and insulin action with the hyperglycemic (125 mg/dl above basal) and euglycemic insulin (40 mU.m-2.min-1) clamps in seven moderately obese subjects before and after a 6-wk exercise training program. Thirty-nine normal-weight, age-matched subjects served as controls. Both fasting plasma insulin concentration and glucose-stimulated (hyperglycemic clamp) insulin secretion were significantly (P less than .001) increased in the obese subjects. After the training program fasting insulin levels decreased by 26% (P less than .01). Insulin secretion in response to hyperglycemia decreased by a similar percentage (P less than .01). Nonetheless, total-body glucose metabolism increased significantly (P less than .05) during the hyperglycemic clamp. With the euglycemic insulin clamp, obese subjects were shown to be significantly (P less than .001) insulin resistant compared with controls. The decrease in total-body glucose uptake resulted from defects in both peripheral glucose disposal and suppression of hepatic glucose production. After the 6-wk training program, insulin-mediated total-body glucose metabolism increased due to significant improvements in peripheral glucose uptake (P less than .01) and more effective suppression of hepatic glucose production (P less than .05). These results indicate that a moderate-intensity physical conditioning program is capable of ameliorating the insulin resistance and reducing glucose-stimulated hyperinsulinemia observed in obese subjects with normal glucose tolerance.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1379-85
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Effect of physical training on insulin action in obesity.
pubmed:affiliation
Division of Diabetes/Endocrinology, Yale University School of Medicine, New Haven, Connecticut.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.