| pubmed-article:3313438 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3313438 | lifeskim:mentions | umls-concept:C0232164 | lld:lifeskim |
| pubmed-article:3313438 | lifeskim:mentions | umls-concept:C0040779 | lld:lifeskim |
| pubmed-article:3313438 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:3313438 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:3313438 | lifeskim:mentions | umls-concept:C1280519 | lld:lifeskim |
| pubmed-article:3313438 | lifeskim:mentions | umls-concept:C0348080 | lld:lifeskim |
| pubmed-article:3313438 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:3313438 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3313438 | pubmed:dateCreated | 1987-12-2 | lld:pubmed |
| pubmed-article:3313438 | pubmed:abstractText | Cardiac and coronary effects of trapidil (Rocornal) and some derivatives were investigated in isolated heart preparations and rabbit hearts in vivo. All substances showed a comparable increase of the coronary flow. Contrary to the cardiotonic influence of trapidil the trapidil derivates induced a negative inotropic effect, possibly due to a weak calcium antagonism. Heart rate was slightly diminished, but in some cases higher doses caused an acute tachycardia. I.v. application of the substances to rabbits in doses of 10 mg/kg and 30 mg/kg induced an initial depression of blood pressure normalizing within 3-5 min. An increase of the myocardial prostacyclin biosynthesis is only demonstrable under trapidil. The results indicate that the cardiac effects of trapidil derivatives are possibly caused by a direct influence on the contractile system and the membrane potential of the cardiac muscle cell. | lld:pubmed |
| pubmed-article:3313438 | pubmed:language | ger | lld:pubmed |
| pubmed-article:3313438 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3313438 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3313438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3313438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3313438 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3313438 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3313438 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3313438 | pubmed:issn | 0031-7144 | lld:pubmed |
| pubmed-article:3313438 | pubmed:author | pubmed-author:MentzPP | lld:pubmed |
| pubmed-article:3313438 | pubmed:author | pubmed-author:MestH JHJ | lld:pubmed |
| pubmed-article:3313438 | pubmed:author | pubmed-author:GiesslerCC | lld:pubmed |
| pubmed-article:3313438 | pubmed:author | pubmed-author:PawelskiK EKE | lld:pubmed |
| pubmed-article:3313438 | pubmed:author | pubmed-author:OrlovaZ RZR | lld:pubmed |
| pubmed-article:3313438 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3313438 | pubmed:volume | 42 | lld:pubmed |
| pubmed-article:3313438 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3313438 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3313438 | pubmed:pagination | 403-6 | lld:pubmed |
| pubmed-article:3313438 | pubmed:dateRevised | 2007-1-29 | lld:pubmed |
| pubmed-article:3313438 | pubmed:meshHeading | pubmed-meshheading:3313438-... | lld:pubmed |
| pubmed-article:3313438 | pubmed:meshHeading | pubmed-meshheading:3313438-... | lld:pubmed |
| pubmed-article:3313438 | pubmed:meshHeading | pubmed-meshheading:3313438-... | lld:pubmed |
| pubmed-article:3313438 | pubmed:meshHeading | pubmed-meshheading:3313438-... | lld:pubmed |
| pubmed-article:3313438 | pubmed:meshHeading | pubmed-meshheading:3313438-... | lld:pubmed |
| pubmed-article:3313438 | pubmed:meshHeading | pubmed-meshheading:3313438-... | lld:pubmed |
| pubmed-article:3313438 | pubmed:meshHeading | pubmed-meshheading:3313438-... | lld:pubmed |
| pubmed-article:3313438 | pubmed:meshHeading | pubmed-meshheading:3313438-... | lld:pubmed |
| pubmed-article:3313438 | pubmed:meshHeading | pubmed-meshheading:3313438-... | lld:pubmed |
| pubmed-article:3313438 | pubmed:meshHeading | pubmed-meshheading:3313438-... | lld:pubmed |
| pubmed-article:3313438 | pubmed:meshHeading | pubmed-meshheading:3313438-... | lld:pubmed |
| pubmed-article:3313438 | pubmed:meshHeading | pubmed-meshheading:3313438-... | lld:pubmed |
| pubmed-article:3313438 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3313438 | pubmed:articleTitle | [The effectiveness of trapidil and some derivatives on heart function under in vitro and in vivo conditions]. | lld:pubmed |
| pubmed-article:3313438 | pubmed:affiliation | Institut für Pharmakologie und Toxikologie, Martin-Luther-Universität Halle-Wittenberg. | lld:pubmed |
| pubmed-article:3313438 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3313438 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:3313438 | pubmed:publicationType | English Abstract | lld:pubmed |
