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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
|
pubmed:dateCreated |
1987-12-2
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pubmed:abstractText |
Cardiac and coronary effects of trapidil (Rocornal) and some derivatives were investigated in isolated heart preparations and rabbit hearts in vivo. All substances showed a comparable increase of the coronary flow. Contrary to the cardiotonic influence of trapidil the trapidil derivates induced a negative inotropic effect, possibly due to a weak calcium antagonism. Heart rate was slightly diminished, but in some cases higher doses caused an acute tachycardia. I.v. application of the substances to rabbits in doses of 10 mg/kg and 30 mg/kg induced an initial depression of blood pressure normalizing within 3-5 min. An increase of the myocardial prostacyclin biosynthesis is only demonstrable under trapidil. The results indicate that the cardiac effects of trapidil derivatives are possibly caused by a direct influence on the contractile system and the membrane potential of the cardiac muscle cell.
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pubmed:language |
ger
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
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pubmed:issn |
0031-7144
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-6
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pubmed:dateRevised |
2007-1-29
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pubmed:meshHeading |
pubmed-meshheading:3313438-Anesthesia,
pubmed-meshheading:3313438-Animals,
pubmed-meshheading:3313438-Electric Stimulation,
pubmed-meshheading:3313438-Epoprostenol,
pubmed-meshheading:3313438-Guinea Pigs,
pubmed-meshheading:3313438-Heart,
pubmed-meshheading:3313438-Heart Rate,
pubmed-meshheading:3313438-Myocardium,
pubmed-meshheading:3313438-Perfusion,
pubmed-meshheading:3313438-Pyrimidines,
pubmed-meshheading:3313438-Rabbits,
pubmed-meshheading:3313438-Trapidil
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pubmed:year |
1987
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pubmed:articleTitle |
[The effectiveness of trapidil and some derivatives on heart function under in vitro and in vivo conditions].
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pubmed:affiliation |
Institut für Pharmakologie und Toxikologie, Martin-Luther-Universität Halle-Wittenberg.
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pubmed:publicationType |
Journal Article,
In Vitro,
English Abstract
|