Linked Life Data

3312936

Source:http://linkedlifedata.com/resource/pubmed/id/3312936

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1987-12-9
pubmed:abstractText
Insulin-related material was measured in acid ethanol extracts of brain, testis, liver, and kidney from adult rats acutely injected with insulin or saline. Insulin injection resulted in a twofold to threefold increase in plasma insulin during a two-hour period after injection. Plasma glucose was greatly depressed. Insulin injection had no effect on the insulin-related material in most areas of brain (cerebral cortex, olfactory bulbs, and medial hypothalamus) and the cerebrospinal fluid; lateral hypothalamus was an exception and paradoxically exhibited a decrease of this material. The testis insulin-related material was unaffected; purification of the testis extracts using the C18 Sep pak method revealed no further difference between the animals. In liver, the insulin-related material was not significantly different in the control and the insulin-injected group; however, we found a significant correlation between this material and plasma insulin within the insulin-injected group. In contrast, insulin injection resulted in an important increase in kidney insulin-related material that paralleled the change in plasma insulin. Thus, like chronic experiments, acute hyperinsulinemia revealed that the insulin-related material was largely independent from blood insulin in tissues that exhibit very different insulin uptake from the blood; kidney appeared to be an exception.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0026-0495
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1067-72
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
The influence of acute hyperinsulinemia on the insulin-related material in brain, testis, liver, and kidney.
pubmed:affiliation
Laboratoire d'Etude du Métabolisme Azoté, INRA-Theix, Ceyrat, France.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't