Linked Life Data

3312317

Source:http://linkedlifedata.com/resource/pubmed/id/3312317

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1987-12-15
pubmed:abstractText
Ninety-one skin biopsy specimens previously identified as lentigo maligna were examined for the presence of microinvasion, using the demonstration of S100 protein within atypical cells as the means for locating these superficial foci. In 14 cases, atypical melanocytes were identified, most often in the papillary dermis. The mean depth of invasion in this group was 0.23 mm with a range of 0.10 mm to 0.75 mm. In these cases, atypical cells were difficult if not impossible to identify in routinely processed sections, either because the invasive cell was a spindle cell variant and indistinguishable from a fibrohistiocytic cell, because the invasive cells were occasionally solitary or in small groups, or because there was an inflammatory infiltrate that obscured the tumor cells. Recent studies of lentigo maligna melanoma have revealed no better prognosis when compared to that of other forms of malignant melanoma after normalization for depth and body location. We therefore advocate close examination of lentigo maligna with the use of appropriate immunohistochemical techniques if there are areas of dermal fibrosis or inflammation that might obscure invasion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0190-9622
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
675-80
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Microinvasive lentigo maligna melanoma.
pubmed:affiliation
Department of Dermatology, University of Miami School of Medicine, FL.
pubmed:publicationType
Journal Article