Linked Life Data

3311458

Source:http://linkedlifedata.com/resource/pubmed/id/3311458

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5 Pt 2
pubmed:dateCreated
1987-12-10
pubmed:abstractText
Plasma norepinephrine (PNE) levels are significantly elevated in patients with endstage congestive heart failure. To assess whether this abnormality is reversible, 32 patients were studied before and 3 to 9 months after orthotopic cardiac transplantation. PNE decreased after the transplant procedure form 739 +/- 363 to 301 +/- 161 pg/ml (p less than .05). In 13 patients, PNE was measured sequentially during the first 3 months after the transplant procedure. PNE decreased from 590 +/- 293 to 321 +/- 208 pg/ml at 2 weeks and remained stable at 1 month (308 +/- 239 pg/ml), 2 months (307 +/- 196 pg/ml), and 3 months (331 +/- 131 pg/ml), even while arterial hypertension developed. No correlation was found between PNE, systolic, diastolic, or mean arterial pressure and cyclosporine A blood levels. These data demonstrate that normalization of plasma levels of norepinephrine occurs shortly after cardiac transplantation in man. This decrease in PNE is probably independent of immunosuppression therapy. Finally, the development of arterial hypertension in cyclosporine A-treated cardiac transplant patients is not due to activation or persistent activation of the sympathetic nervous system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0009-7322
pubmed:author
pubmed:issnType
Print
pubmed:volume
76
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
V62-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Normalization of sympathetic nervous system function after orthotopic cardiac transplant in man.
pubmed:affiliation
Department of Medicine, University of Minnesota Medical School, Minneapolis.
pubmed:publicationType
Journal Article