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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1987-12-14
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pubmed:abstractText |
1 The effects of a 2-substituted analogue of adenosine 5'-triphosphate (ATP), 2-methylthioadenosine triphosphate (2-methylthio ATP) have been studied on insulin secretion and flow rate of the isolated pancreas of the rat, perfused in the presence of glucose (8.3 mM). 2 2-Methylthio ATP (16.5-1650 nM) increased insulin secretion in a biphasic and concentration-dependent manner; the kinetics were comparable to those previously obtained with ATP. A comparison of relative potency between ATP and 2-methylthio ATP showed that 2-methylthio ATP was 45 times more potent than ATP. 3 2-Methylthio ATP also provoked a transient decrease of the flow rate in a concentration-dependent manner but at concentrations (165-825 microM) about 1000 fold higher than those needed to increase insulin secretion. A comparison of relative potency between the natural derivative and 2-methylthio ATP showed that 2-methylthio ATP was only twice as potent as ATP. 4 These and other previous results (with phosphate-modified analogues of ATP) provide evidence for two different types of P2-purinoceptors on endocrine cell and vessel cells of the pancreas. A P2Y subtype, mediating an increase of insulin secretion, is present on the beta cell of the pancreas. A P2X subtype, mediating vasoconstriction, is present on the vascular bed of the rat pancreas.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-1195136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-13952078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-2935231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-2983813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-2985402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-2990944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-2996968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-3006665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-3532817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-393523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-4749478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-4907149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-6303799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-6317121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3311264-7035188
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
783-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:3311264-Adenosine Triphosphate,
pubmed-meshheading:3311264-Animals,
pubmed-meshheading:3311264-Blood Flow Velocity,
pubmed-meshheading:3311264-Insulin,
pubmed-meshheading:3311264-Islets of Langerhans,
pubmed-meshheading:3311264-Male,
pubmed-meshheading:3311264-Pancreas,
pubmed-meshheading:3311264-Rats,
pubmed-meshheading:3311264-Rats, Inbred Strains,
pubmed-meshheading:3311264-Receptors, Purinergic,
pubmed-meshheading:3311264-Thionucleotides
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pubmed:year |
1987
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pubmed:articleTitle |
Evidence for two different P2-purinoceptors on beta cell and pancreatic vascular bed.
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pubmed:affiliation |
Faculté de Médecine, Laboratoire de Pharmacologie, UA 599 du CNRS, Montpellier, France.
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pubmed:publicationType |
Journal Article,
In Vitro
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