| pubmed-article:3311026 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3311026 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:3311026 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:3311026 | lifeskim:mentions | umls-concept:C0040711 | lld:lifeskim |
| pubmed-article:3311026 | lifeskim:mentions | umls-concept:C0597295 | lld:lifeskim |
| pubmed-article:3311026 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:3311026 | lifeskim:mentions | umls-concept:C0063681 | lld:lifeskim |
| pubmed-article:3311026 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3311026 | pubmed:dateCreated | 1987-11-6 | lld:pubmed |
| pubmed-article:3311026 | pubmed:abstractText | Insulin and insulin-related growth factor 1 (IGF-1) increase by 1.5-1.6-fold the rate of [3H]leucine incorporation into protein in primary monolayer cultures of chick-embryo fibroblasts (CEF); half-maximal hormone concentrations are 10 and 0.25 nM respectively. To investigate the mechanism of this effect, a rapid method is used to prepare a lysate from CEF which is active in protein synthesis. Lysate derived from cells treated for 30-150 min with insulin synthesized protein at 1.8-3.0-fold greater rate than did controls; the increased rate persisted for 20 min in vitro. Pactamycin (0.5 microM), an inhibitor of peptide-chain initiation, inhibited protein synthesis by 50% in lysates derived from insulin-treated and control cells. Thus insulin and IGF-1 cause an increase in the protein-synthesis rate in vivo, which persists in cell-free protein-synthesizing lysates of CEF. | lld:pubmed |
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| pubmed-article:3311026 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3311026 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3311026 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3311026 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3311026 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3311026 | pubmed:month | May | lld:pubmed |
| pubmed-article:3311026 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:3311026 | pubmed:author | pubmed-author:YoungMM | lld:pubmed |
| pubmed-article:3311026 | pubmed:author | pubmed-author:AvruchJJ | lld:pubmed |
| pubmed-article:3311026 | pubmed:author | pubmed-author:PierceM WMW | lld:pubmed |
| pubmed-article:3311026 | pubmed:author | pubmed-author:CoombsKK | lld:pubmed |
| pubmed-article:3311026 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3311026 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:3311026 | pubmed:volume | 244 | lld:pubmed |
| pubmed-article:3311026 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3311026 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3311026 | pubmed:pagination | 239-42 | lld:pubmed |
| pubmed-article:3311026 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:3311026 | pubmed:meshHeading | pubmed-meshheading:3311026-... | lld:pubmed |
| pubmed-article:3311026 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3311026 | pubmed:articleTitle | Control by insulin and insulin-related growth factor 1 of protein synthesis in a cell-free translational system from chick-embryo fibroblasts. | lld:pubmed |
| pubmed-article:3311026 | pubmed:affiliation | Howard Hughes Medical Institute Laboratories, Harvard Medical School, Massachusetts General Hospital, Boston 02114. | lld:pubmed |
| pubmed-article:3311026 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3311026 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
